Protein name:
Midkine (MK) ;
Alternative:
Retinoic acid-induced differentiation factor ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer (By similarity). Interacts with ALK.
Function:
Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation (By similarity). Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development.
Subcellular Location:
Secreted
Protein Attributes:
50:
MQHRGFFLLA | LLALLVVTSA | VAKKKEKVKK | GSECSEWTWG | PCTPSSKDCG |
100:
MGFREGTCGA | QTQRVHCKVP | CNWKKEFGAD | CKYKFESWGA | CDGSTGTKAR |
140:
QGTLKKARYN | AQCQETIRVT | KPCTSKTKSK | TKAKKGKGKD |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
Polyclonal Antibody for Mouse MK
Polyclonal Antibody for Mouse MK
Polyclonal Antibody for Mouse MK
Monoclonal Antibody for Mouse MK
Monoclonal Antibody for Mouse MK
Monoclonal Antibody for Mouse MK
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Salivary gland .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE OF 1-42
6.
"Neointima formation in a restenosis model is suppressed in midkine-deficient mice."
Horiba M.
,
Kadomatsu K.
,
Nakamura E.
,
Muramatsu H.
,
Ikematsu S.
,
Sakuma S.
,
Hayashi K.
,
Yuzawa Y.
,
Matsuo S.
,
Kuzuya M.
,
Kaname T.
,
Hirai M.
,
Saito H.
,
Muramatsu T.
J. Clin. Invest.105:489-495(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION